منابع مشابه
The Serenity Prayer for acute GVHD.
expression to predict the clinical response to tipifarnib and etoposide. RASGRP1 is a guanine nucleotide exchange factor (GEF) that specifically activates RAS, and Aprataxin is a member of the histine triad family of nucleotide hydrolsases involved in the repair of DNA strand breaks. 3 The two-gene expression ratio (RASGRP1/APTX) was identified by analyzing gene expression profiles in bone marr...
متن کاملAdvances in predicting acute GVHD.
Acute graft-versus-host disease (GVHD) is a leading cause of non-relapse mortality following allogeneic haematopoietic cell transplantation. Attempts to improve treatment response in clinically-established GVHD have not improved overall survival, often due to the increased risk of infectious complications. Alternative approaches to decrease GVHD-related morbidity and mortality have focused on t...
متن کاملPrayer-marks Heralding Acute Coronary Syndrome
We read, with interest, the case report on extension of prayer-marks by Cangiano et al. and its association with worsening of the underlying chronic disease (1). We report a case where the occurrence of a similar skin lesion preceded an episode of acute coronary syndrome. A 45-year old man presented with sudden onset of severe retrosternal chest pain radiating to the found to be associated with...
متن کاملThe best endpoint for acute GVHD treatment trials.
The optimal primary endpoint for acute graft-versus-host disease (GVHD) therapeutic trials has not been established. In a retrospective analysis, we examined the response of 864 patients who received prednisone 60 mg/m(2)/d for 14 days, followed by an 8-week taper, as initial therapy for acute GVHD from 1990-2007 at the University of Minnesota. Patients received grafts of human leukocyte antige...
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ژورنال
عنوان ژورنال: Blood
سال: 2012
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2011-11-388215